Wheeling is a city in Ohio and Marshall counties in the U.S. state of West Virginia. Located almost entirely in Ohio County, of which it is the county seat, it lies along the Ohio River in the foothills of the Appalachian Mountains. Wheeling was originally a settlement in the British colony of Virginia, and later the second largest city in the Commonwealth of Virginia. Wheeling was where creation of West Virginia was planned, and it was the first capital of the new state. Due to its location along major transportation routes, including the Ohio River, National Road, and the B&O Railroad, Wheeling became a manufacturing center in the late nineteenth century. After experiencing the closing of factories and substantial population loss following World War II, Wheeling's major industries now include healthcare, education, law and legal services, entertainment and tourism, and energy.